Welcome Wandering!
You have 3 components involved in your issue and I assume there are also at least 3 places to solve it.
For LibreCAD I can tell you to use the Modify -> Move tool and move the whole drawing to achieve a correct processing (Y up I think).
See
https://librecad.readthedocs.io/en/latest/ref/tools.html?highlight=move#modifyWith a little experience in CNC machining I would say, that this is the worst solution.
Usually it's the job of the CAM tool to place the object correct into the machine space.
Or CAD and CAM work with their absolute origins and the machine has capabilities to relocate the processing origin to the mounted object.
Anyhow, it depends on the used tools and machines and their possibilities to find the best place to solve it.
At least, when it works by moving the drawing, everything is fine.
investing less than half an hour into Search function can save hours or days of waiting for a solution