No, it is not possible this way.
What you can do, for instance, if you have a drawing made for A1 format, print a part of it on an A4 sheet.
In Print Preview you can shift around the sheet to the desired position.
But if you export to pdf there is this issue:https://forum.librecad.org/PDF-File-Size-management-tp5722455.html
The only other way I can think of is to draw a mask of nearly white filling (solid hatch, and white would appear black) with a rectangular opening.